Concepedia

Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve

Attila Kristóf, Zoltán Husti, István Koncz, Zsófia Kohajda, Tamás Szél, Viktor Juhász, Péter Biliczki, Norbert Jost, István Baczkó, Julius Gy. Papp,

PLoS ONE · 2012 · 20 citations · 31 references

DOIFull text

Open access

Abstract

Diclofenac at therapeutic concentrations and even at high dose does not prolong repolarization markedly and does not increase the risk of arrhythmia in normal heart. However, high dose diclofenac treatment may lengthen repolarization and enhance proarrhythmic risk in hearts with reduced repolarization reserve.

References

31

Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis

Claire Bombardier, Loren Laine, Alise Reicin et al. · New England Journal of Medicine · 2000 · 4K citations · Full text

Restricting Excessive Cardiac Action Potential and QT Prolongation

Norbert Jost, László Virág, Miklós Bitay et al. · Circulation · 2005 · 381 citations

Drug and chemical blood-level data 2001

Charles L. Winek · Forensic Science International · 2001 · 355 citations

, , +5

Downregulation of Delayed Rectifier K<sup>+</sup>Currents in Dogs With Chronic Complete Atrioventricular Block and Acquired Torsades de Pointes

Paul G.A. Volders, Karin R. Sipido, Marc A. Vos et al. · Circulation · 1999 · 249 citations · Full text

Enhanced Susceptibility for Acquired Torsade de Pointes Arrhythmias in the Dog With Chronic, Complete AV Block Is Related to Cardiac Hypertrophy and Electrical Remodeling

Marc A. Vos, S. H. Marieke de Groot, S. Cora Verduyn et al. · Circulation · 1998 · 246 citations · Full text