Multiple Endocrine Organ Refractoriness to Trophic Hormone Stimulation

Abstract

Case Studies1 August 1965Multiple Endocrine Organ Refractoriness to Trophic Hormone StimulationA Patient With an Enlarged Sella Turcica and Increased FSH SecretionSTEPHEN J. GORDON, M.D., ARNOLD M. MOSES, M.D.STEPHEN J. GORDON, M.D.Search for more papers by this author, ARNOLD M. MOSES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-313 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPituitary tumors are usually nonfunctioning, the associated loss of end organ function being due to diminished trophic hormone secretion. It has been noted, however, that single primary end organ failure can result in production of a trophic hormone producing tumor (1). The following is a report of a patient initially thought to have a pituitary tumor with hypopituitarism but who had increased follicle-stimulating hormone (FSH) excretion and no thyroidal, adrenal, or gonadal responsiveness to trophic hormone stimulation. We believe this is the first such case to be reported.CASE HISTORYPatient C. F., a 47-year-old white male, was first admitted...References1. DENTGADSDENFURTH JNELJ: On the relation between thyroid depression and pituitary tumor induction in mice. Cancer Res. 15: 70, 1955. MedlineGoogle Scholar2. ALBERT A: Procedure for routine clinical determination of urinary gonadotropin. Proc. Mayo Clin. 30: 552, 1955. MedlineGoogle Scholar3. KLEINFELTERALBRIGHTGRISWALD HFFGC: Experience with a quantitative test for normal or decreased amounts of follicle stimulating hormone in the urine in endocrinological diagnoses. J. Clin. Endocr. 3: 529, 1943. CrossrefGoogle Scholar4. BOYCEBEADLES RCF: Enlargement of the hypophysis cerebri in myxedema, with remarks upon hypertrophy of the hypophysis associated with changes in the thyroid body. J. Path. Bact. 1: 223, 1893. CrossrefGoogle Scholar5. GILLILANDSTRUDWICK ICJI: Clinical application of an assay of TSH in relation to exophthalmus. Brit. Med. J. 1: 378, 1956. CrossrefMedlineGoogle Scholar6. CAUGHEY JE: The aetiology of pituitary tumors: the role of hypogonadism and hypothyroidism. Aust. Ann. Med. 6: 93, 1957. MedlineGoogle Scholar7. TANDLERGROSS JS: Über der einfluss der kastration aufden organismus. II. Die Skopzen. Arch. Entwickl.-Mech. Org. 30: 236, 1910. CrossrefGoogle Scholar8. KELLY LW: Ovarian dwarfism with a pituitary tumor. J. Clin. Endocr. 23: 50, 1963. CrossrefMedlineGoogle Scholar9. VAN WYKGRUMBACH JJMM: Syndrome of precocious menstruation and galactorrhea: an example of hormonal overlap in pituitary feedback. J. Pediat. 57: 416, 1960. CrossrefGoogle Scholar10. LLOYD CW: Central nervous system regulation of endocrine function in the human, in Advances in Neuroendocrinology, edited by NALBANDOV, A. V. University of Illinois Press, Urbana, 1963, p. 460. Google Scholar11. NELSONMEAKINTHORN DHJWGW: ACTH producing pituitary tumor following adrenalectomy for Cushing's syndrome. Ann. Intern. Med. 52: 560, 1960. LinkGoogle Scholar12. MONTGOMERYWELBOURNMCCAUGHEYGLEADHILL DARBWTCA: Pituitary tumors manifested after adrenalectomy for Cushing's syndrome. Lancet 2: 707, 1959. CrossrefMedlineGoogle Scholar13. COSTELLO RT: Subclinical adenoma of the pituitary gland. Amer. J. Path. 12: 205, 1936. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Syracuse, New YorkFrom the Department of Medicine, Veterans Administration Hospital and State University of New York, Upstate Medical Center, Syracuse, N. Y.Requests for reprints should be addressed to Arnold M. Moses, M.D., 800 Irving Avenue, Syracuse, N. Y. 13210. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe clinicopathological characteristics of gonadotroph cell adenoma: A study of 118 casesPituitary enlargement with target organ deficiency: Hypothyroidism and hypogonadismTumors of the PituitaryClinical and histopathological characteristics of gonadotropin-producing pituitary adenomasGONADOTROPHIN-SECRETING PITUITARY TUMOUR: REPORT AND REVIEWTriplet gestation following thyroid replacement in a patient with infertility, hyperprolactinemia, and enlarged sella secondary to hypothyroidism**Supported in part by grants from the Edward Crown, M.D., Memorial Foundation.Pituitary thyrotropic adenoma associated with congenital hypothyroidismVolume of sella turcica in normals and patients with peripheral endocrinopathies or idiopathic gonadotropin deficiencyGONADOTROPHIN AND ALPHA SUBUNIT SECRETION BY HUMAN ‘FUNCTIONLESS’ PITUITARY ADENOMAS IN CELL CULTURE: LONG TERM EFFECTS OF LUTEINIZING HORMONE RELEASING HORMONE AND THYROTROPHIN RELEASING HORMONEHuman pituitary gonadotropic adenoma; histological, immunocytochemical, and ultrastructural and hormonal studies in eight casesProlactin-secreting pituitary adenomas in womenThyrotropin- and Gonadotropin-Secreting Pituitary AdenomasGonadotroph cell adenoma of the pituitary in a woman with long-standing hypogonadismPituitary Adenomas Associated with Elevated Blood Follicle-Stimulating Hormone Levels: A Histologic, Immunocytologic, and Electron Microscopic Study of Two Cases*Normalization of Visual Fields Following Bromocriptine Treatment in Hyperprolactinemic Patients with Visual Field Constriction*Pituitary Enlargement, Pituitary Failure, and Primary HypothyroidismAPOSTOLOS G. VAGENAKIS, M.D., KEVIN DOLE, M.D., LEWIS E. BRAVERMAN, M.D., F.A.C.P.Pathophysiologie und Klinik der HypophysentumorenPostoperative Diagnostik und Substitutionstherapie bei HypophysentumorenPituitary Enlargement Secondary to Untreated Primary HypogonadismBRUCE F. BOWER, M.D., F.A.C.P. 1 August 1965Volume 63, Issue 2Page: 313-316KeywordsExcretionFollicle stimulating hormoneFollicle-stimulating hormoneHormonal therapyHormonesHospital medicinePituitary tumorsProlactinThyroidThyroid hormones Issue Published: 1 August 1965 PDF DownloadLoading ...