Concepedia

A Central Role for CD68(+) Macrophages in Hepatopulmonary Syndrome

Thenappan Thenappan, Ankush Goel, Glenn Marsboom, Yong-Hu Fang, Péter T. Tóth, Hannah J. Zhang, Hidemi Kajimoto, Zhigang Hong, Jonathan Paul, Christian Wietholt,

American Journal of Respiratory and Critical Care Medicine · 2010 · 186 citations · 39 references

DOI

Abstract

HPS results from intravascular accumulation of CD68(+)macrophages. An occult proliferative vasculopathy may explain the occasional transition to portopulmonary hypertension. Macrophage depletion may have therapeutic potential in HPS.

References

39

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

Reversal of experimental pulmonary hypertension by PDGF inhibition

Ralph T. Schermuly · Journal of Clinical Investigation · 2005 · 1K citations · Full text

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Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat.

J Kountouras, Barbara H. Billing, P. J. Scheuer · PubMed · 1984 · 687 citations · Full text

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Selective and Specific Macrophage Ablation Is Detrimental to Wound Healing in Mice

Rita E. Mirza, Luisa A. DiPietro, Timothy J. Koh · American Journal Of Pathology · 2009 · 603 citations · Full text

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An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats

Sébastien Bonnet, Evangelos D. Michelakis, Christopher J. Porter et al. · Circulation · 2006 · 577 citations