Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers

Polymers containing enzymatically degradable bonds, 8. Degradation of oligopeptide sequences in <i>N</i>‐(2‐hydroxypropyl)methacrylamide copolymers by bovine spleen cathepsin B

Pavla Rejmanová, Jindřich Kopeček, Jan Pohl et al. · Die Makromolekulare Chemie · 1983 · 264 citations

Macromolecular Chemistry, Engineering, Peptide Science +20

A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies.

A. Trouet, Michèle Masquelier, R. Baurain et al. · Proceedings of the National Academy of Sciences · 1982 · 233 citations

Free Dnr, Glycobiology, Immunology +22

Polymers containing enzymatically degradable bonds, 7. Design of oligopeptide side‐chains in poly[<i>N</i>‐(2‐hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by lysosomal enzymes

Ruth Duncan, Hazel C. Cable, John B. Lloyd et al. · Die Makromolekulare Chemie · 1983 · 194 citations

Pharmaceutical Science, Macromolecular Chemistry, Engineering +23

Polymers containing enzymatically degradable bonds, 1. Chymotrypsin catalyzed hydrolysis of <i>p</i>‐nitroanilides of phenylalanine and tyrosine attached to side‐chains of copolymers of <i>N</i>‐(2‐hydroxypropyl)methacrylamide

Jindřich Kopeček, Pavla Rejmanová, Vladimír Chytrý · Die Makromolekulare Chemie · 1981 · 141 citations

Bioorganic Chemistry, Engineering, Enzymatic Modification +16

Enzymatic cleavage of side chains of synthetic water‐soluble polymers

J. Drobník, Jindřich Kopeček, J. Labský et al. · Die Makromolekulare Chemie · 1976 · 120 citations

Macromolecular Chemistry, Bioorganic Chemistry, Engineering +17