Concepedia

K-252a, a potent inhibitor of protein kinase C from microbial origin.

Hiroshi Kase, Kazuyuki Iwahashi, Yuzuru Matsuda

The Journal of Antibiotics · 1986 · 334 citations · 18 references

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Concepts

Abstract

K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent inhibitory activity on protein kinase C. The IC50 value was 32.9 nM.

References

18

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

Mark A. Bradford · Analytical Biochemistry · 1976 · 225.4K citations

, , +7

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

Hiroyoshi Hidaka, Masaki Inagaki, Sachiyo Kawamoto et al. · Biochemistry · 1984 · 2.7K citations

, , +14

Adenosine 3‘,5‘-Phosphate in Biological Materials

R.W. Butcher, Earl W. Sutherland · Journal of Biological Chemistry · 1962 · 2.1K citations · Full text

, , +13

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

Yoshimi Takai, Akira Kishimoto, Yasushi Iwasa et al. · Journal of Biological Chemistry · 1979 · 1.1K citations · Full text

, , +14

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

Ushio Kikkawa, Yoshimi Takai, R Minakuchi et al. · Journal of Biological Chemistry · 1982 · 1K citations · Full text

, , +14