Topological ?frustration? in multispanning E. coli inner membrane proteins

Rapid and efficient site-specific mutagenesis without phenotypic selection.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1985 · 7.3K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +15

Membrane protein structure prediction

Gunnar von Heijne · Journal of Molecular Biology · 1992 · 1.7K citations

Life Sciences, Biochemistry, Biophysics +12

Intracellular protein topogenesis

Günter Blobel · Proceedings of the National Academy of Sciences · 1980 · 1.4K citations · Full text

Life Sciences, Biochemistry, Cell Biology +7

The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis

Donald M. Engelman, Thomas A. Steitz · Cell · 1981 · 880 citations

Natural Sciences, Biochemistry, Biophysics +14

The distribution of positively charged residues in bacterial inner membrane proteins correlates with the trans‐membrane topology

Gunnar von Heijne · The EMBO Journal · 1986 · 880 citations

Life Sciences, Biochemistry, Microbiology +13