Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region

Chromatin immunoprecipitation and microarray-based analysis of protein location

Tong Ihn Lee, Sarah E. Johnstone, Richard A. Young · Nature Protocols · 2006 · 780 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

Tatsuya Sueyoshi, Takeshi Kawamoto, Igor N. Zelko et al. · Journal of Biological Chemistry · 1999 · 671 citations · Full text

Medicine, Molecular Biology, Pharmacology +17

The Phenobarbital Response Enhancer Module in the Human Bilirubin Udp–Glucuronosyltransferase Ugt1a1 Gene and Regulation by the Nuclear Receptor Car

Junko Sugatani, Hiroyuki Kojima, Akiko Ueda et al. · Hepatology · 2001 · 378 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

Stephanie Faucette, Tong-Cun Zhang, Rick Moore et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 289 citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +11

Fluvoxamine Inhibition and Carbamazepine Induction of the Metabolism of Clozapine

Markus Jerling, Leif Lindström, Ulf Bondesson et al. · Therapeutic Drug Monitoring · 1994 · 280 citations

Pharmacy, Pharmacokinetics, Pharmacology +15