Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells

Incidence of local recurrence and second primary tumors in resected stage I lung cancer

Nael Martini, Manjit S. Bains, Michael Burt et al. · Journal of Thoracic and Cardiovascular Surgery · 1995 · 979 citations · Full text

Medicine, Oncology, Surgery +13

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition

Hanna Y. Irie, Rachel V. Pearline, Dorre A. Grueneberg et al. · The Journal of Cell Biology · 2005 · 590 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Individual development and uPA–receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer

M. M. Heiss, Heike Allgayer, Klaus Uwe Gruetzner et al. · Nature Medicine · 1995 · 252 citations

Medicine, Oncology, Pathology +14

Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: establishment of working models for human micrometastases.

Elmar Putz, K. Witter, Sonja Offner et al. · PubMed · 1999 · 189 citations

Medicine, Cell Biology, Oncology +12

Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding

Lisa Héron‐Milhavet, Céline Franckhauser, Vanessa Rana et al. · Molecular and Cellular Biology · 2006 · 175 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17