Toll-like receptor 2 mediates early inflammation by leptospiral outer membrane proteins in proximal tubule cells

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

Life Sciences, Immunology, Molecular Biology +13

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity · 1999 · 3.4K citations · Full text

Life Sciences, Immunology, Microbiology +13

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

Jesse C. Chow, Donna W. Young, Douglas T. Golenbock et al. · Journal of Biological Chemistry · 1999 · 2K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

Atsutoshi Yoshimura, Egil Lien, Robin R. Ingalls et al. · The Journal of Immunology · 1999 · 1.2K citations · Full text

Life Sciences, Immunology, Microbiology +17

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

Ruey‐Bing Yang, Melanie R. Mark, Alane Gray et al. · Nature · 1998 · 1.2K citations

Life Sciences, Immunology, Molecular Biology +10