Catalytic Asymmetric Carbonyl–Ene Reactions

Abstract

Practical options for catalytic and enantioselective CC bond formation have been extended by recent developments reported by the Carreira and Mikami groups in reactions of aldehydes with alkenes containing an allylic H atom [Eq. (a)]. These studies link two fascinating and topical areas of organic synthesis—carbonyl–ene chemistry and the use chiral Lewis acids.