Enantionselektive Synthese des L‐Threonins

Abstract

An Enantionselective Synthesis of L‐Threonine An enantioselective synthesis of L‐threonine ( 1 ) is described. Racemic ethyl 2‐acetamido‐3‐oxobutyrate ( 6 ) was synthesized from ethyl acetoacetate ( 2 ) [4][5] and then transformed to the epimeric optically active alcohols 7a and 7b by microbiological reduction with Saccharomyces rouxii . The Mixture 7a/7b could be converted to 1 by slightly modified, known Methods in a yield of ca. 52% with respect to 7a/7b .