Silent mutations in the gene encoding the p53 protein are preferentially located in conserved amino acid positions and splicing enhancers

The rapid generation of mutation data matrices from protein sequences

David T. Jones, William R. Taylor, Janet M. Thornton · Computer applications in the biosciences · 1992 · 7.1K citations

Life Sciences, Bioinformatics, Computational Biology +10

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

M Nei, T Gojobori · Molecular Biology and Evolution · 1986 · 5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Amino Acid Difference Formula to Help Explain Protein Evolution

Richard Grantham · Science · 1974 · 2.4K citations

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ESEfinder: a web resource to identify exonic splicing enhancers

Luca Cartegni · Nucleic Acids Research · 2003 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

The IARC TP53 database: New online mutation analysis and recommendations to users

Magali Olivier, Rosalind A. Eeles, Monica Hollstein et al. · Human Mutation · 2002 · 1.3K citations

Medicine, Genetics, Oncology +14