Necic acid synthons. Part 5. Total synthesis of (±)-retronecic acid and related compounds via zinc-mediated coupling of halogeno-esters

Abstract

Zinc-mediated coupling of suitably substituted halogeno esters affords access to (±)-retronecic acid (2) and related intermediates. These approaches lead to racemic retronecic acid on the one hand and to a diastereoisomeric mixture of the acid on the other.