Electrophysiological Effects of Dofetilide in an In Vitro Model of “Border Zone” Between Normal and Ischemic/Reperfused Myocardium

Abstract

Dofetilide 5 nmol/L decreased APD(90) dispersion between NZ and AZ and reduced the early ES-induced arrhythmias. However, dofetilide 50 nmol/L increased APD(90) dispersion, and at 10 and 50 nmol/L, it increased the late spontaneous arrhythmias.

References

Page 1

	Year	Citations
Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. Luc M. Hondeghem, Dirk J. Snyders Circulation Reduced EffectivenessTranslational MedicineHeart FailureCardiogenic ShockDevice Therapy	1990	608
Flow of "injury" current and patterns of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Evidence for two different arrhythmogenic mechanisms. Michiel J. Janse, F J van Capelle, H. Morsink, Circulation Research Cardiac MuscleIsolated PorcineCardiogenic ShockCardiovascular DiseaseCardiac Physiology	1980	606
Extracellular Potassium Modulation of Drug Block of I<sub>Kr</sub> Tao Yang, Dan M. Roden Circulation	1996	431
Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide. Edward Carmeliet Journal of Pharmacology and Experimental Therapeutics	1992	323
Intravenous Dofetilide, a Class III Antiarrhythmic Agent, for the Termination of Sustained Atrial Fibrillation or Flutter Rodney H. Falk, Arthur Pollak, Steven Singh, Journal of the American College of Cardiology	1997	217
Comparison of the effects of regional ischemia, hypoxia, hyperkalemia, and acidosis on intracellular and extracellular potentials and metabolism in the isolated porcine heart. H Moréna, Michiel J. Janse, J W Fiolet, Circulation Research Animal PhysiologyMedicinePhysiologyExtracellular PotentialsHypoxia (Medicine)	1980	197
The "border zone" in myocardial ischemia. An electrophysiological, metabolic, and histochemical correlation in the pig heart. M J Janse, Juan Cinca, H Moréna, Circulation Research Myocardial IschemiaCardiovascular DiseaseBorder ZoneCardiac PhysiologyPhysiology	1979	193
Ventricular activation patterns of spontaneous and induced ventricular rhythms in canine one-day-old myocardial infarction. Evidence for focal and reentrant mechanisms. Nabil El‐Sherif, Rahul Mehra, William B. Gough, Circulation Research Cardiac MuscleHeart FailureInduced Ventricular RhythmsPacemaker SiteIsochronal Maps	1982	171
Influence of Dofetilide on QT-Interval Duration and Dispersion at Various Heart Rates During Exercise in Humans Jean-Louis De ́molis, Christian Funck‐Brentano, Jacques Ropers, Circulation	1996	71
Electrophysiologic profile and efficacy of intravenous dofetilide (UK-68,798), a new class III antiarrhythmic drug, in patients with sustained monomorphic ventricular tachycardia Y Bashir, Poul-Erik Bloch Thomsen, J.H. Kingma, The American Journal of Cardiology Electrophysiologic ProfileCardiogenic ShockElectrophysiological EvaluationCardiovascular DiseaseMedicine	1995	64

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