Clinicopathologiclmplications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

Masato Orita, Youichi Suzuki, Takao Sekiya et al. · Genomics · 1989 · 3.5K citations

Sensitive Detection, Polymerase Chain Reaction, Genetic Analysis +12

Amplification of a gene encoding a p53-associated protein in human sarcomas

Jonathan D. Oliner, Kenneth W. Kinzler, Paul S. Meltzer et al. · Nature · 1992 · 2K citations · Full text

Tumor Biology, Human Sarcomas, P53-associated Protein +7

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

Jonathan D. Oliner, Jennifer A. Pietenpol, Sam Thiagalingam et al. · Nature · 1993 · 1.5K citations

Tumor Biology, Oncogenic Agent, Medicine +8

Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience.

Paul A. Meyers, Glenn Heller, John H. Healey et al. · Journal of Clinical Oncology · 1992 · 684 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

Fredrick S. Leach, Takashi Tokino, Paul S. Meltzer et al. · PubMed · 1993 · 538 citations

Pathology, Cancer Biology, Tumor Biology +16