Effects of Dexmedetomidine on Microregional O2 Balance during Reperfusion after Focal Cerebral Ischemia

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.5K citations · Full text

Medicine, Neuroscience, Surgery +17

Neuroprotection by the α2-Adrenoreceptor Agonist Dexmedetomidine in a Focal Model of Cerebral Ischemia

Carolina M. Maier, Gary K. Steinberg, Guo Hua Sun et al. · Anesthesiology · 1993 · 236 citations · Full text

Medicine, Anesthesiology, Neurosurgery +16

Acute Focal Ischemia-Induced Alterations in MAP2 Immunostaining: Description of Temporal Changes and Utilization as a Marker for Volumetric Assessment of Acute Brain Injury

Deborah A. Dawson, John M. Hallenbeck · Journal of Cerebral Blood Flow & Metabolism · 1996 · 180 citations

Medicine, Neurobiology, Neuroscience +16

Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

Yong-Man Zhu, Can-Can Wang, Long Chen et al. · Brain Research · 2012 · 174 citations

Medicine, Neuroscience, Pharmacology +14

Effect of Dexmedetomidine on Cerebral Blood Flow Velocity, Cerebral Metabolic Rate, and Carbon Dioxide Response in Normal Humans

John C. Drummond, Andrew V. Dao, David M. Roth et al. · Anesthesiology · 2008 · 174 citations · Full text

Medicine, Neurology, Pharmacology +14