Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.4K citations · Full text

Mca Occlusion, Cerebral Vascular Regulation, Neurovascular Disease +18

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia

Alessandro Alessandrini, Shobu Namura, Michael A. Moskowitz et al. · Proceedings of the National Academy of Sciences · 1999 · 465 citations · Full text

Dexmedetomidine Improves Neurologic Outcome from Incomplete Ischemia in the Rat Reversal by the α2-Adrenergic Antagonist Atipamezole

William E. Hoffman, E. Kochs, Christian Werner et al. · Anesthesiology · 1991 · 284 citations · Full text

Pharmacotherapy, Experimental Pharmacology, Anesthetic Administration +24

Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin

Kamal Rahmouni, Donald A. Morgan, Gina Morgan et al. · Journal of Clinical Investigation · 2004 · 182 citations

Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway

Yajing Yuan, Qulian Guo, Zhi Ye et al. · Brain Research · 2010 · 146 citations

Apoptosis, Cell Death, Social Sciences +17