Concepedia

Poly(ester amine)-mediated, Aerosol-delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis

Cheng‐Xiong Xu, Dhananjay Jere, Hua Jin, Seung-Hee Chang, Youn-Sun Chung, Jiyoung Shin, Ji‐Eun Kim, Sung Jin Park, Yong-Hoon Lee, Chanhee Chae,

American Journal of Respiratory and Critical Care Medicine · 2008 · 101 citations · 41 references

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Abstract

The use of poly(ester amine) serves as an effective carrier, and aerosol delivery of Akt1 siRNA may be a promising approach for lung cancer treatment and prevention.

References

41

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

Leisa Johnson, Kim L. Mercer, Doron C. Greenbaum et al. · Nature · 2001 · 1.2K citations

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Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

Christian B. Matranga, Yukihide Tomari, Chanseok Shin et al. · Cell · 2005 · 1.1K citations · Full text

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