Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-γ, and APOE) on human fertility

A simple salting out procedure for extracting DNA from human nucleated cells

S.A. Miller, Dale D. Dykes, Herbert F. Polesky · Nucleic Acids Research · 1988 · 20.4K citations · Full text

Chromatin, Dna Sequencing, Molecular Biological Method +11

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

Samir S. Deeb, Lluís Fajas, Masami Nemoto et al. · Nature Genetics · 1998 · 1.3K citations · Full text

Insulin Resistance, Metabolic Syndrome, Molecular Pharmacology +14

Genetic associations with human longevity at the APOE and ACE loci

François Schächter, Laurence Faure-Delanef, Frédérique Guénot et al. · Nature Genetics · 1994 · 1.1K citations

Biology, Genetic Associations, Lifespan Extension +10

Human longevity at the cost of reproductive success

Rudi G. J. Westendorp, Thomas B. L. Kirkwood · Nature · 1998 · 616 citations

Lifespan Extension, Infertility, Reproductive Success +8

A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.

Mauricio Serrato, Ali J. Marian · Journal of Clinical Investigation · 1995 · 338 citations · Full text

Vascular Disease, Genetics, Genetic Epidemiology +24