A Novel Approach to the CP‐225,917 and CP‐263,114 Core

Abstract

A Rh-catalyzed generation of a carbenoid and its intramolecular trapping, followed by a divinylcyclopropane rearrangement and a radical cyclization, are the crucial reactions in a new strategy for constructing the bicyclo[4.3.1]dec-1(9),4-diene-10-one framework of the natural products in the title. The resulting model compound 1 differs from this target core only in the configuration of the quaternary center.