Concepedia

C−H Bond Functionalization in the Synthesis of Fused 1,2,3-Triazoles

Jane Panteleev, Karolin Geyer, Angélica Aguilar‐Aguilar, Letian Wang, Mark Lautens

Organic Letters · 2010 · 63 citations · 39 references

DOI

Abstract

A highly modular approach to fused 1,2,3-triazoles has been developed featuring a one-pot procedure combining copper(I) catalyzed azide-alkyne cycloaddition and palladium-catalyzed C-H bond functionalization. A class of structurally unique heterocycles was synthesized in good yields.

References

39

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.4K citations

, , +12

Peptidotriazoles on Solid Phase:  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides

Christian W. Tornøe, Caspar Christensen, Morten Meldal · The Journal of Organic Chemistry · 2002 · 8.4K citations

, , +15

Catalysts for Suzuki−Miyaura Coupling Processes:  Scope and Studies of the Effect of Ligand Structure

Timothy E. Barder, Shawn D. Walker, Joseph R. Martinelli et al. · Journal of the American Chemical Society · 2005 · 1.8K citations

A synthetic method for formyl→ethynyl conversion (RCHO→RCCH or RCCR′)

E. J. Corey, P.L. Fuchs · Tetrahedron Letters · 1972 · 1.6K citations

Click Chemistry: Versatility and Control in the Hands of Materials Scientists

Himabindu Nandivada, Xiaoman Jiang, Joerg Lahann · Advanced Materials · 2007 · 693 citations · Full text

, , +14