Overexpression of miR‐122 promotes the hepatic differentiation and maturation of mouse ESCs through a miR‐122/FoxA1/HNF4a‐positive feedback loop

Abstract

Overexpression of miR-122 at an appropriate stage could promote hepatic differentiation and maturation by regulating the balance between proliferation and differentiation, as well as the balance between EMT and MET, partially through a miR-122/FoxA1/HNF4a-positive feedback loop.