CysLT2 receptor-mediated AQP4 up-regulation is involved in ischemic-like injury through activation of ERK and p38 MAPK in rat astrocytes

Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke

Geoffrey T. Manley, Miki Fujimura, Tonghui Ma et al. · Nature Medicine · 2000 · 1.5K citations

Osmoregulation, Ischemic Stroke, Neurophysiology +13

Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method

Eugen Solenov, Hiroyuki Watanabe, Geoffrey T. Manley et al. · American Journal of Physiology-Cell Physiology · 2004 · 333 citations

Calcein Fluorescence, Primary Astrocyte Cultures, Cytoskeleton +22

Aquaporin‐4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess

Orin Bloch, Marios C. Papadopoulos, Geoffrey T. Manley et al. · Journal of Neurochemistry · 2005 · 178 citations

Hyperosmolar Mannitol Stimulates Expression of Aquaporins 4 and 9 through a p38 Mitogen-activated Protein Kinase-dependent Pathway in Rat Astrocytes

Hajime Arima, Naoki Yamamoto, Kazuya Sobue et al. · Journal of Biological Chemistry · 2003 · 173 citations · Full text

Inhibition of AQP4 expression in astrocytes by RNAi determines alterations in cell morphology, growth, and water transport and induces changes in ischemia related genes

Grazia Paola Nicchia, Antonio Frigeri, Grazia Maria Liuzzi et al. · The FASEB Journal · 2003 · 133 citations

Gene Expression Pattern, Glioma, Cellular Physiology +17