Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.8K citations · Full text

Inflammation, Signal Transduction, Oxysterol +12

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Nancy A. Thornberry, Herbert G. Bull, Jimmy Calaycay et al. · Nature · 1992 · 2.6K citations

Inflammation, Cytokine, Granulocyte +6

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Yong Gu, Keisuke Kuida, Hiroko Tsutsui et al. · Science · 1997 · 1.1K citations

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

Kathrin S. Michelsen, Michelle Wong, Prediman K. Shah et al. · Proceedings of the National Academy of Sciences · 2004 · 1K citations · Full text

Vascular Disease, Innate Immune System, Immunology +17

A Unified Model for Apical Caspase Activation

Kelly M. Boatright, Martin Renatus, Fiona L. Scott et al. · Molecular Cell · 2003 · 941 citations · Full text

Signal Transduction, Molecular Physiology, Signaling Pathway +10