Priming and Extending: A UbcH5/Cdc34 E2 Handoff Mechanism for Polyubiquitination on a SCF Substrate

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

Vincent Chau, John W. Tobias, Andreas Bachmair et al. · Science · 1989 · 1.5K citations

Protein Assembly, Glycobiology, Molecular Biology +21

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

Ning Zheng, Brenda A. Schulman, Langzhou Song et al. · Nature · 2002 · 1.5K citations

Structural Biology, Molecular Biology, Protein X-ray Crystallography

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

Dorota Skowyra, Karen Craig, Mike Tyers et al. · Cell · 1997 · 1.2K citations · Full text

Scf Ubiquitin-ligase Complex, Protein Function, Signal Transduction +10

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

Zhijian J. Chen, Lana Parent, Tom Maniatis · Cell · 1996 · 955 citations · Full text

Signal Transduction, Signaling Pathway, Molecular Regulation +11

A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

R. M. Renny Feldman, Craig C. Correll, Kenneth B. Kaplan et al. · Cell · 1997 · 809 citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +8