Perineural Invasion Associated With Recurrent Sporadic Multiple Self-healing Squamous Carcinomas

Abstract

<h3>To the Editor.—</h3> Ferguson Smith¹did not realize that he had discovered an autosomal-dominant trait when he reported a single case of multiple self-healing squamous carcinomas (MSHSC) in 1934.²It is now recognized that both familial and sporadic types of MSHSC exist. Both entities are now included in the designation of multiple Ferguson-Smith keratoacanthomas. The MSHSC are occasionally known for an extremely mutilating course and fatal outcome. The patient initially described by Ferguson Smith was again cited 14 years later for extensive nasal destruction that required a prosthesis.³Charteris⁴described a patient with MSHSC who died as a result of an extensive recurrent anal lesion. We report a patient with sporadic MSHSC who experienced extensive recurrent perineural invasion of the right supratrochlear nerve. This observation suggests that perineural invasion by keratoacanthoma should not be regarded as an entirely benign condition. <h3>Report of a Case.—</h3> A 44-year-old