Concepedia

Differential Activation of Mitogen-activated Protein Kinases in Ischemic and Anesthetic Preconditioning

Rafaela da Silva, Thomas Grampp, Thomas Pasch, Marcus Schaub, Michael Zaugg

Anesthesiology · 2003 · 75 citations · 40 references

DOIFull text

Open access

Abstract

Although MAPKs may orchestrate cardioprotection as triggers and mediators in IPC, they are devoid of triggering, but they may have mediator effects in APC.

References

40

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

Orlando F. Bueno · The EMBO Journal · 2000 · 782 citations · Full text

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Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site

Peter R. Young, Megan M. McLaughlin, Sanjay Kumar et al. · Journal of Biological Chemistry · 1997 · 573 citations · Full text

Isoflurane Mimics Ischemic Preconditioning via Activation of KATPChannels 

Judy R. Kersten, Todd J. Schmeling, Paul S. Pagel et al. · Anesthesiology · 1997 · 422 citations · Full text

Mitochondrial PKCε and MAPK Form Signaling Modules in the Murine Heart

Christopher Baines, Jun Zhang, Guang-Wu Wang et al. · Circulation Research · 2002 · 420 citations

Inhibition of Extracellular Signal–Regulated Kinase Enhances Ischemia/Reoxygenation–Induced Apoptosis in Cultured Cardiac Myocytes and Exaggerates Reperfusion Injury in Isolated Perfused Heart

Tianli Yue, Chuanlin Wang, Juan-Li Gu et al. · Circulation Research · 2000 · 418 citations

, , +20