Concepedia

The Influence of p38 Mitogen-Activated Protein Kinase Inhibitor on Synthesis of Inflammatory Cytokine Tumor Necrosis Factor Alpha in Spinal Cord of Rats with Chronic Constriction Injury

Li Xu, Yuguang Huang, Xuerong Yu, Jianying Yue, Nan Yang, Pingping Zuo

Anesthesia & Analgesia · 2007 · 52 citations · 22 references

DOI

Abstract

p38 MAPK activation is one aspect of the signaling cascade that culminates in TNF-alpha synthesis and contributes to mechanical allodynia after peripheral nerve injury.

References

22

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Gary J. Bennett, Yuanyu Xie · Pain · 1988 · 5.3K citations

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p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain

Shan‐Xue Jin, Zhi-Ye Zhuang, Clifford J. Woolf et al. · Journal of Neuroscience · 2003 · 855 citations · Full text

Tumor Necrosis Factor-α Induces Mechanical Allodynia after Spinal Nerve Ligation by Activation of p38 MAPK in Primary Sensory Neurons

Maria Schäfers, Camilla I. Svensson, Claudia Sommer et al. · Journal of Neuroscience · 2003 · 520 citations · Full text

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ERK MAP Kinase Activation in Superficial Spinal Cord Neurons Induces Prodynorphin and NK-1 Upregulation and Contributes to Persistent Inflammatory Pain Hypersensitivity

Ru‐Rong Ji, Katia Befort, Gary J. Brenner et al. · Journal of Neuroscience · 2002 · 451 citations · Full text

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Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation.

Maria Schäfers, Doo H. Lee, Dominik Brors et al. · PubMed · 2003 · 278 citations · Full text

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