Concepedia

Methadone is a local anaesthetic-like inhibitor of neuronal Na+ channels and blocks excitability of mouse peripheral nerves

Carsten Stoetzer, Katrin Kistner, Thomas Stüber, M. Wirths, Volker Schulze, Thorben Doll, Nilufar Foadi, Florian Wegner, J. Ahrens, Andreas Leffler

British Journal of Anaesthesia · 2014 · 26 citations · 30 references

DOI

Concepts

References

30

HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain

Edward C. Emery, Gareth T. Young, Esther Berrocoso et al. · Science · 2011 · 352 citations

, , +12

Perineural Dexmedetomidine Added to Ropivacaine for Sciatic Nerve Block in Rats Prolongs the Duration of Analgesia by Blocking the Hyperpolarization-activated Cation Current

Chad M. Brummett, Elizabeth K. Hong, Allison M. Janda et al. · Anesthesiology · 2011 · 320 citations · Full text

, , +17

Stereoselective Block of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers

Chin B. Eap, Séverine Crettol, Jürg Schläpfer et al. · Clinical Pharmacology & Therapeutics · 2007 · 255 citations

, , +15

QTc interval prolongation associated with intravenous methadone

Craig Kornick, Michael J. Kilborn, Juan Santiago‐Palma et al. · Pain · 2003 · 240 citations

, , +9

Cytotoxicity of Local Anesthetics in Human Neuronal Cells

Rosalia Perez-Castro, Sohin R. Patel, Zayra V. Garavito‐Aguilar et al. · Anesthesia & Analgesia · 2009 · 239 citations

, , +15