Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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Cent Inhibition, Inhibitory Activity, Biochemistry +8

The Many Roles for Fluorine in Medicinal Chemistry

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Medicinal Chemistry, Molecular Sciences, Bioorganic Chemistry +15

Crystal structure of the human angiotensin-converting enzyme–lisinopril complex

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Crystal Structure, Biochemistry, Protein X-ray Crystallography +3

[13] Evolutionary families of metallopeptidases

Neil D. Rawlings, A. John Barrett · Methods in enzymology on CD-ROM/Methods in enzymology · 1995 · 809 citations

Biology, Phylogenetics, Natural Sciences +4

Structure of thermolysin refined at 1.6 Å resolution

Michael Holmes, Brian W. Matthews · Journal of Molecular Biology · 1982 · 444 citations

Protein X-ray Crystallography, Structural Biology, Structure Elucidation +1