Activation of wild-type and ΔF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

John R. Riordan, Johanna M. Rommens, Bat-Sheva Kerem et al. · Science · 1989 · 7.4K citations

Life Sciences, Genetics, Molecular Genetics +12

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

Christine E. Bear, Canhui Li, Norbert Kartner et al. · Cell · 1992 · 946 citations

Life Sciences, Cell Biology, Molecular Biology +14

Submucosal glands are the predominant site of CFTR expression in the human bronchus

John F. Engelhardt, James R. Yankaskas, Stephen A. Ernst et al. · Nature Genetics · 1992 · 649 citations

Medicine, Cell Biology, Physiology +13

Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In <i>Xenopus</i> Oocytes

Mitchell L. Drumm, Daniel J. Wilkinson, Lisa S. Smit et al. · Science · 1991 · 499 citations

Life Sciences, Genetics, Molecular Biology +17

Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion

B. Q. Shen, Walter E. Finkbeiner, Jeffrey J. Wine et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 1994 · 348 citations

Life Sciences, Cell Biology, Pharmacology +17