Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Han Cho, James Mu, Jason K. Kim et al. · Science · 2001 · 1.8K citations

Life Sciences, Biochemistry, Molecular Biology +17

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

Gang Xu, Doris A. Stoffers, Joel F. Habener et al. · Diabetes · 1999 · 1.2K citations

Life Sciences, Endocrinology, Physiology +16

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

Michael A. Nauck, N. Kleine, C. �rskov et al. · Diabetologia · 1993 · 1.1K citations · Full text

Medicine, Endocrinology, Internal Medicine +15

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

Bernard Thorens · Proceedings of the National Academy of Sciences · 1992 · 905 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

Rüdiger Göke, H. C. Fehmann, Thomas Linn et al. · Journal of Biological Chemistry · 1993 · 838 citations · Full text

Life Sciences, Endocrinology, Pharmacology +17