Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro

Primary structure and expression of a functional human glucocorticoid receptor cDNA

Stanley M. Hollenberg, Cary Weinberger, Estelita S. Ong et al. · Nature · 1985 · 1.9K citations · Full text

Life Sciences, Endocrinology, Molecular Biology +12

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

Sidney Farber, Louis K. Diamond, Robert D. Mercer et al. · New England Journal of Medicine · 1948 · 1.8K citations

Pharmacy, Pharmacology, Pharmacotherapy +11

Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody–associated vasculitis

Kirsten de Groot, Niels Rasmussen, P A Bacon et al. · Arthritis & Rheumatism · 2005 · 796 citations

Life Sciences, Pharmacology, Pharmacotherapy +14

A Comparison of Methotrexate with Placebo for the Maintenance of Remission in Crohn's Disease

Brian G. Feagan, Richard N. Fedorak, E. Jan Irvine et al. · New England Journal of Medicine · 2000 · 727 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +7

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

Bruce N. Cronstein, Dwight Naime, Edward Ostad · Journal of Clinical Investigation · 1993 · 678 citations · Full text

Medicine, Immunology, Pharmacology +16