Serum Creatine Phosphokinase (CPK) Activity in Disorders of Heart and Skeletal Muscle

Abstract

Article1 December 1964Serum Creatine Phosphokinase (CPK) Activity in Disorders of Heart and Skeletal MuscleJOSEPH W. HESS, M.D., RODERICK P. MACDONALD, PH.D, RICHARD J. FREDERICK, M.S., ROBERT N. JONES, M.D., JOANN NEELY, M.D., DAVID GROSS, M.D.JOSEPH W. HESS, M.D., RODERICK P. MACDONALD, PH.D, RICHARD J. FREDERICK, M.S., ROBERT N. JONES, M.D., JOANN NEELY, M.D., DAVID GROSS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1015 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSerum enzyme studies have come to occupy an increasingly important place in clinical medicine. Accurate interpretation of elevated serum enzyme activity may be complicated, however, because many of the serum enzymes used as diagnostic aids in clinical medicine are found in several types of tissues. If a clinical situation is simple and only one type of tissue is diseased, then interpretation of the test results may not pose a problem. If, on the other hand, more than one tissue is affected, the physician may have difficulty interpreting an elevation if he is aware of multiple organ disease; or he may...References1. OLIVER IT: A spectrophotometric method for the determination of creatine phosphokinase and myokinase. Biochem. J. 61: 116, 1955. CrossrefMedlineGoogle Scholar2. TANZERGILVARG MLC: Creatine and creatine kinase measurement. J. Biol. Chem. 234: 3201, 1959. CrossrefMedlineGoogle Scholar3. EBASHITOYOKURAMOMOISUGATA SYHH: High creatine phosphokinase activity of sera of progressive muscular dystrophy patients. J. Biochem. (Tokyo) 46: 103, 1959. Google Scholar4. OKINAKAKUMAGAIEBASHISUGATAMOMOITOYOKURAFUJIE SHSHHYY: Serum creatine phosphokinase activity in progressive muscular dystrophy and neuromuscular diseases. Arch. Neurol. (Chicago) 4: 520, 1961. 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Author, Article, and Disclosure InformationAffiliations: Detroit, MichiganFrom the Department of Medicine, Wayne State University School of Medicine and Receiving Hospital, and the Departments of Medicine and Pathology, Harper Hospital, Detroit, Mich.This study was supported by research grants from the Michigan Heart Association and the Muscular Dystrophy Association of America, Inc.Portions of this study were presented before the Michigan Regional Meeting of the American College of Physicians, December 7-8, 1962, and the First Sectional Meeting of the American College of Physicians, November 21, 1963, Detroit, Mich.Requests for reprints should be addressed to Joseph W. Hess, M.D., Department of Medicine, Wayne State University School of Medicine, 1401 Rivard St., Detroit 7, Mich. 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IntoxicationGutartige recessiv x-chromosomal vererbte MuskeldystrophieSerum Enzymology in the Diagnosis of Myocardial Infarction and Related Cardiovascular ConditionsThe Contribution of Isozymes of Serum Lactic Dehydrogenase (LDH) to the Diagnosis of Specific Organ InjuryIsoenzymes in Clinical DiagnosisThe Muscular Dystrophies 1 December 1964Volume 61, Issue 6Page: 1015-1028KeywordsAminotransferasesCreatinine phosphokinaseDehydrogenasesEnzymesHospital medicinePancreasPolymyositisResearch grantsResearch laboratoriesSkeletal muscles Issue Published: 1 December 1964 PDF downloadLoading ...