Oligonucleotide Analogues with Terminal 3′-3′- and 5′-5′-Internucleotidic Linkages as Antisense Inhibitors of Viral Gene Expression

Abstract

Abstract Oligodeoxynucleotides with terminal 3′-3′- and 5′-5′-internucleotidic linkages were found to be stabilized towards intracellular degradation and to inhibit gene expression in vitro and in vivo at concentrations of 10-30 pM.