The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

D. M. Blow, Jens J. Birktoft, B. S. Hartley · Nature · 1969 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +3

Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.

Kiichiro Nakajima, James C. Powers, Bonnie M. Ashe et al. · Journal of Biological Chemistry · 1979 · 595 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution

N.C.J. Strynadka, Hiroyuki Adachi, Susan E. Jensen et al. · Nature · 1992 · 526 citations

Life Sciences, Biochemistry, Chemistry +15

Amides. 3. Experimental and Theoretical Studies of the Effect of the Medium on the Rotational Barriers for N,N-Dimethylformamide and N,N-Dimethylacetamide

Kenneth B. Wiberg, Paul R. Rablen, Daniel J. Rush et al. · Journal of the American Chemical Society · 1995 · 316 citations

Natural Sciences, Chemistry, Physics +9

The mechanisms of reactions of .beta.-lactam antibiotics

Michael I. Page · Accounts of Chemical Research · 1984 · 191 citations

Pharmacy, Medicinal Chemistry, Antimicrobial Pharmacology +6