Concepedia

Residual CD95-Pathway Function in Children With Autoimmune Lymphoproliferative Syndrome Is Independent From Clinical State and Genotype of CD95 Mutation

Hans Fuchs, Carsten Posovszky, Georgia Lahr, Jutte van der Werff ten Bosch, Thomas Boehler, Klaus‐Michael Debatin

Pediatric Research · 2009 · 12 citations · 30 references

DOI

Concepts

References

30

Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor.

Frank Kischkel, Stefan Hellbardt, Iris Behrmann et al. · The EMBO Journal · 1995 · 2.1K citations · Full text

, , +13

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Nils Holler, Rossana Zaru, Olivier Micheau et al. · Nature Immunology · 2000 · 1.9K citations

, , +14

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

Galen H. Fisher, Fredric J Rosenberg, Stephen E. Straus et al. · Cell · 1995 · 1.5K citations · Full text

, , +14

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

Frédéric Rieux‐Laucat, Françoise Le Deist, Claire Hivroz et al. · Science · 1995 · 1.3K citations

, , +17

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

Hyung J. Chun, Lixin Zheng, Manzoor Ahmad et al. · Nature · 2002 · 692 citations

, , +16