Science · 1977 · 684 citations · 19 references
Life SciencesMicrobiologyFood MicrobiologyMedical MicrobiologyAntimicrobial TherapyBactericidal AgentsColony-forming Unit AssaysEscherichia ColiLactoferrin ActivityMetal-binding Properties
Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contingent upon the metal-chelating properties of the lactoferrin molecule.
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Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.
Spitznagel Jk, Dalldorf Fg, Leffell Ms et al. · PubMed · 1974 · 337 citations