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Retrobulbar optic neuritis associated with infliximab.
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2003
Year
Ocular DiseaseVasculitisImmunologyInflammatory ArthritisMagnetic Resonance ImagingRheumatoid DisorderSurgical PathologyInflammatory Rheumatic DiseaseOptic NeuritisNeuroimmunologyRheumatoid ArthritisRheumatologyAutoimmune DiseaseOphthalmologyRheumatic DiseasesOptic NeuropathyOcular PathologyRetrobulbar Optic NeuritisMedicine
Foroozan R, Buono LM, Sergott RC, et al. Retrobulbar optic neuritis associated with infliximab. Arch Ophthalmol 2002;120:985–6. Infliximab, an IgG antibody against tumor necrosis factor alpha (TNF-α), is administered as an intravenous infusion in the treatment of rheumatoid arthritis. Reported side effects include exacerbation of symptoms and radiographic evidence of demyelinating disease. The authors report a potentially new adverse effect of infliximab: optic neuritis in a 55-year-old woman with rheumatoid arthritis. The onset of optic neuritis was 3 days after her twelfth dose of the drug. Magnetic resonance imaging (MRI) showed gadolinium enhancement of the affected optic nerve. The patient was treated with IV and PO steroids with improved visual acuity and resolution of the visual field defect.