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A new direct method for the synthesis of enantiomerically pure protected α-amino acids
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1989
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EngineeringBiochemistryAcid ChloridesUltrasonic ActivationOrganozinc ReagentPeptide SynthesisOrganic ChemistryStereoselective SynthesisNew Direct MethodPharmacologyAsymmetric CatalysisEnantioselective SynthesisBiomolecular Engineeringα-Amino Acids
The organozinc reagent (2), prepared from the protected β-iodo alanine derivative (3) using ultrasonic activation, is efficiently acylated using acid chlorides in the presence of (Ph3P)2PdCl2 to give high yields of enantiomerically pure protected γ-keto α-amino acids (4).