Patients treated with unfractionated heparin during open heart surgery are at high risk to form antibodies reactive with heparin:platelet factor 4 complexes

Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin

Theodore E. Warkentin, Mark N. Levine, Jack Hirsh et al. · New England Journal of Medicine · 1995 · 2.3K citations · Full text

Medicine, Hematology, Pharmacotherapy +15

A diagnostic test for heparin-induced thrombocytopenia

D Sheridan, C Carter, JG Kelton · Blood · 1986 · 702 citations · Full text

Medicine, Hematology, Pathology +14

Bleeding complications associated with cardiopulmonary bypass

RC Woodman, Harker La · Blood · 1990 · 626 citations · Full text

Medicine, Perioperative Medicine, Surgery +12

Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells.

Gian Paolo Visentin, S E Ford, James G. Scott et al. · Journal of Clinical Investigation · 1994 · 555 citations · Full text

Medicine, Hematology, Immunology +17

Heparin-associated thrombocytopenia: isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen.

Andreas Greinacher, B. Pötzsch, Jean Amiral et al. · PubMed · 1994 · 472 citations

Medicine, Hematology, Immunology +13