Concepedia

Swertifrancheside, an HIV-Reverse Transcriptase Inhibitor and the First Flavone-Xanthone Dimer, from Swertia franchetiana

Jiannong Wang, Cui-Ying Hou, Yong‐Long Liu, Long-Ze Lin, Roberto R. Gil, Geoffrey A. Cordell

Journal of Natural Products · 1994 · 66 citations · 0 references

DOI

Concepts

Abstract

The first flavone-xanthone C-glucoside, swertifrancheside, was isolated from Swertia franchetiana, and its structure was elucidated on the basis of spectroscopic analysis as 1,5,8-trihydroxy-3-methoxy-7-(5',7',3'',4''- tetrahydroxy-6'-C-beta-D-glucopyranosyl-4'-oxy-8'-flavyl)-xanthone . This compound was a moderately potent inhibitor of HIV reverse transcriptase.