Concepedia

Biomarkers for assessment of pharmacologic activity for a vascular endothelial growth factor (VEGF) receptor inhibitor, PTK787/ZK 222584 (PTK/ZK): translation of biological activity in a mouse melanoma metastasis model to phase I studies in patients with advanced colorectal cancer with liver metastases

Lucy Lee, Sunil Sharma, Bruno Morgan, Peter R. Allegrini, Christian Schnell, Josef Brueggen, Robert Cozens, Mark A. Horsfield, Clemens Guenther, W P Steward,

Cancer Chemotherapy and Pharmacology · 2005 · 63 citations · 15 references

DOI

Concepts

References

15

A new look at the statistical model identification

Hirotugu Akaike · IEEE Transactions on Automatic Control · 1974 · 50.7K citations · Full text

, , +9

A Simplex Method for Function Minimization

J. A. Nelder, R. Mead · The Computer Journal · 1965 · 28.9K citations

, , +8

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

J M Wood, Guido Bold, Elisabeth Buchdunger et al. · PubMed · 2000 · 847 citations

, , +16

Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria

Stephanie Green, Geoffrey R. Weiss · Investigational New Drugs · 1992 · 616 citations

, , +14

Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models.

Theodora Voskoglou-Nomikos, Joseph L. Pater, Lesley Seymour · PubMed · 2003 · 524 citations

, , +14