Concepedia

A facile method for the synthesis of oxindole based quaternary α-aminonitriles via the Strecker reaction

Yun‐Lin Liu, Feng Zhou, Junjie Cao, Cong‐Bin Ji, Miao Ding, Jian Zhou

Organic & Biomolecular Chemistry · 2010 · 122 citations · 114 references

DOI

Concepts

Abstract

The direct alpha-cyanoamination of isatins using TMSCN has been developed, which is carried out in methanol without any catalyst. A new bifunctional cinchona alkaloid-based phosphinamide catalyst 7 could promote the Strecker reaction of isatins derived ketimine with TMSCN in up to 74% ee.

References

114

Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids

Christiane Marti, Erick M. Carreira · European Journal of Organic Chemistry · 2003 · 1.4K citations

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Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C‐3 Position

Feng Zhou, Yun‐Lin Liu, Jian Zhou · Advanced Synthesis & Catalysis · 2010 · 1.2K citations

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Highly Enantioselective Conjugate Addition of Nitromethane to Chalcones Using Bifunctional Cinchona Organocatalysts

Benedek Vakulya, Szilárd Varga, Tibor Soós · Organic Letters · 2005 · 979 citations

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Schiff Base Catalysts for the Asymmetric Strecker Reaction Identified and Optimized from Parallel Synthetic Libraries

Matthew S. Sigman, Eric N. Jacobsen · Journal of the American Chemical Society · 1998 · 895 citations

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Highly Enantioselective Conjugate Addition of Nitromethane to Chalcones Using Bifunctional Cinchona Organocatalysts.

Benedek Vakulya, Szilárd Varga, Antal Csámpai et al. · ChemInform · 2005 · 816 citations · Full text

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