In Vitro Metabolism of R(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a Cannabinoid Receptor Agonist

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

John W. Daly, D. M. JERINA, Bernhard Witkop · Cellular and Molecular Life Sciences · 1972 · 599 citations

Medicine, Chemistry, Toxicology +10

Hydroxylation-Induced Migration: The NIH Shift

Gordon Guroff, J Renson, Sidney Udenfriend et al. · Science · 1967 · 520 citations

Life Sciences, Biochemistry, Cell Biology +6

Conformationally restrained analogs of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor

Thomas E. D'Ambra, Kimberly G. Estep, Malcolm R. Bell et al. · Journal of Medicinal Chemistry · 1992 · 294 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

The synthetic cannabinoid WIN55,212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain

Daniel Bridges, Kamran Ahmad, Andrew S.C. Rice · British Journal of Pharmacology · 2001 · 219 citations · Full text

Medicine, Neuroscience, Pharmacology +16

Role of the arene oxide-oxepin system in the metabolism of aromatic substrates

D. M. JERINA, Jeanette M. Daly, Bernhard Witkop et al. · Archives of Biochemistry and Biophysics · 1968 · 215 citations

Medicine, Biochemistry, Pharmacology +10