Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

Charles B. Nemeroff, Erik Widerlöv, Garth Bissette et al. · Science · 1984 · 1.5K citations

Life Sciences, Neuroscience, Psychiatry +17

Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development

George W. Smith, Jean-Michel Aubry, F. Dellu et al. · Neuron · 1998 · 900 citations · Full text

Veterinary Medicine, Neurobiology, Neuroscience +17

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

Astrid Zobel, Thomas Nickel, Heike Künzel et al. · Journal of Psychiatric Research · 2000 · 704 citations

Medicine, Pharmacology, Psychiatry +14

The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders

Isabella Heuser, Alexander Yassouridis · Journal of Psychiatric Research · 1994 · 661 citations

Medicine, Endocrinology, Psychiatry +9

Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior

MP Stenzel-Poore, Serge Rivest, G F Koob et al. · Journal of Neuroscience · 1994 · 475 citations · Full text

Life Sciences, Endocrinology, Neuroscience +17