Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column

A gene complex controlling segmentation in Drosophila

E. B. Lewis · Nature · 1978 · 3.9K citations

Life Sciences, Developmental Biology, Genetics +10

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

Life Sciences, Developmental Biology, Molecular Biology +12

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

The molecular basis for metameric pattern in the <i>Drosophila</i> embryo

Michael Akam · Development · 1987 · 1K citations

Life Sciences, Biology, Developmental Biology +17

The murine and Drosophila homeobox gene complexes have common features of organization and expression

Anthony Graham, Nancy Papalopulu, Robb Krumlauf · Cell · 1989 · 1K citations

Life Sciences, Genetics, Molecular Genetics +11