Influence of cytotoxic doses of 4-hydroxynonenal on selected neurotransmitter receptors in PC-12 cells

A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90)

Ellen Borenfreund, James A. Puerner · Methods in Cell Science · 1985 · 885 citations

Pharmacy, Toxicology, Toxicokinetics +8

Role of oxidative stress in paraquat‐induced dopaminergic cell degeneration

Alison L. McCormack, Jennifer G. Atienza, Louisa C. Johnston et al. · Journal of Neurochemistry · 2005 · 274 citations

Life Sciences, Neuroscience, Toxicology +17

4-Hydroxynonenal Induces Adaptive Response and Enhances PC12 Cell Tolerance Primarily through Induction of Thioredoxin Reductase 1 via Activation of Nrf2

Zhi-Hua Chen, Yoshiro Saito, Yasukazu Yoshida et al. · Journal of Biological Chemistry · 2005 · 195 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and α-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease

Hafiz Mohmmad Abdul, D. Allan Butterfield · Free Radical Biology and Medicine · 2006 · 142 citations · Full text

Life Sciences, Neurobiology, Neuroscience +14

Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.

Kôji Uchida, Earl R. Stadtman · Proceedings of the National Academy of Sciences · 1992 · 125 citations

Life Sciences, Biochemistry, Molecular Biology +15