Allergen-Induced mRNA Expression of IL-5, but Not of IL-4 and IFN-γ, in Peripheral Blood Mononuclear Cells Is a Key Feature of Clinical Manifestation of Seasonal Allergic Rhinitis

Abstract

This study has clearly highlighted an interesting and new concept that IL-4 is implicated in allergen sensitization but not in clinical manifestation, and that IL-5 may not be a feature of atopy in itself but seems to be a hallmark of clinical manifestation of ongoing atopic diseases.