Hepatitis C Virus Not Found in Fulminant Non-A, Non-B Hepatitis

Abstract

Brief Reports15 July 1991Hepatitis C Virus Not Found in Fulminant Non-A, Non-B HepatitisTeresa L. Wright, MD, Henry Hsu, MD, Elizabeth Donegan, MD, Stephen Feinstone, MD, Harry Greenberg, MD, Alexandra Read, MD, Nancy L. Ascher, MD, John P. Roberts, MD, John R. Lake, MDTeresa L. Wright, MD, Henry Hsu, MD, Elizabeth Donegan, MD, Stephen Feinstone, MD, Harry Greenberg, MD, Alexandra Read, MD, Nancy L. Ascher, MD, John P. Roberts, MD, John R. Lake, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-2-111 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNon-A, non-B hepatitis is a diagnosis of exclusion in patients with acute hepatitis but without serologic evidence of hepatitis A or hepatitis B viral infection. The recently identified hepatitis C virus (HCV) accounts for most cases of non-A, non-B hepatitis after blood transfusion or intravenous drug abuse (1, 2). However, it is not known whether HCV causes fulminant non-A, non-B hepatitis. To address this issue, we used a sensitive and specific polymerase chain reaction to detect HCV RNA in patients with fulminant hepatic failure of unknown cause.Patients and MethodsWe studied 15 patients who were referred for liver transplantation...References1. AlterPurcellShih HRJ. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med. 1989;321:1494-500. CrossrefMedlineGoogle Scholar2. KuoChooAlter GQH. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989;244:362-4. CrossrefMedlineGoogle Scholar3. CristianoDi BisceglieHoofnagleFeinstone KAJS. Hepatitis C viral RNA in serum of patients with chronic non-A, non-B hepatitis: detection by polymerase chain reaction using multiple primer sets. Hepatology. [In press]. Google Scholar4. O'GradyAlexanderHayllarWilliams JJKR. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 1989;97:439-45. CrossrefMedlineGoogle Scholar5. Dienstag J. Non-A, non-B hepatitis I. Recognition, epidemiology, and clinical features. Gastroenterology. 1983;85:439-62. CrossrefMedlineGoogle Scholar6. BernuauRueffBenhamou JBJ. Fulminant and subfulminant liver failure: definitions and causes. Semin Liv Dis. 1986;6:97-106. CrossrefMedlineGoogle Scholar7. MutoSugiharaOhnishiMoriwakiNishioka YJHHK. Anti-hepatitis C virus antibody prevails in fulminant hepatic failure. Gastroenterol Jpn. 1990;25:32-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Teresa L. Wright, MD; Henry Hsu, MD; Elizabeth Donegan, MD; Stephen Feinstone, MD; Harry Greenberg, MD; Alexandra Read, MD; Nancy L. Ascher, MD; John P. Roberts, MD; John R. Lake, MDAffiliations: From the Department of Veterans Affairs Medical Center and the University of California, San Francisco, San Francisco, California; Palo Alto Department of Veterans Affairs Medical Center, Palo Alto, California; Stanford University, Stanford, California; and the Laboratory of Hepatitis Research, Food and Drug Administration, Bethesda, Maryland. For current author addresses, see end of text. 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Mosley, MD, Jorge Rakela, MD 15 July 1991Volume 115, Issue 2Page: 111-112KeywordsFood and Drug AdministrationHepatitisHepatitis AHepatitis BHepatitis C virusLiver transplantationPolymerase chain reactionRNARenal diseasesResearch laboratories ePublished: 1 December 2008 Issue Published: 15 July 1991 PDF downloadLoading ...